Determination of preferential interaction parameters by multicomponent diffusion. applications to poly(ethylene glycol)-salt-water ternary mixtures.

Effect of macromolecular polydispersity on diffusion coefficients measured by Rayleigh interferometry.

Rayleigh interferometry has been extensively used for the precise determination of diffusion coefficients for binary and ternary liquid mixtures. For ternary mixtures, the 2x2 matrix of multicomponent diffusion coefficients is obtained. Polydispersity adds complexity to the meaning of these measured diffusion coefficients. Here we discuss three important issues of polydispersity regarding the d...

Macromolecular hydration compared with preferential hydration and their role on macromolecule-osmolyte coupled diffusion.

Hydration and preferential hydration of macromolecules are two distinct properties of their multicomponent aqueous solutions. We have experimentally investigated ternary diffusion in a macromolecule-osmolyte-water system in order to characterize and compare these two independent quantities and to experimentally establish their role on the phenomenon of coupled diffusion. Specifically, we report...

Study of Surface Tension of Binary Mixtures of Poly (Ethylene Glycol) in Water and Poly (Propylene Glycol) in Ethanol and its Modeling Using Neural Network

Quaternary diffusion coefficients in a protein-polymer-salt-water system determined by rayleigh interferometry.

We have experimentally investigated multicomponent diffusion in a protein-polymer-salt-water quaternary system. Specifically, we have measured the nine multicomponent diffusion coefficients, D(ij), for the lysozyme-poly(ethylene glycol)-NaCl-water system at pH 4.5 and 25 degrees C using precision Rayleigh interferometry. Lysozyme is a model protein for protein-crystallization and enzymology stu...

Effect of particle size on salt-induced diffusiophoresis compared to Brownian mobility.

For ternary polymer-salt-water systems at low polymer concentration (0.5%, w/w), we have experimentally investigated the effect of polymer size on polymer diffusiophoresis (i.e., polymer migration induced by a salt concentration gradient) and salt osmotic diffusion (i.e., salt migration induced by a polymer concentration gradient). Specifically, Rayleigh interferometry was employed to measure t...